I want to make structural analysis of lysosomal proteins found in mammals. To make start, I would like to retrieve as many structures as possible from the biological database (PDB). These structures show dynamic structural features (many fold types, variation in size and multiple cellular location). I have tried two general strategies - search by keywork "lysosomal" and get results based on deposition date of structure. I also found an article on proteomic analysis for lysosomal proteins where the author had provided GI for each proteins. In this case, I made protein blast against PDB and selected the lysosomal proteins. Both ways were quite time consuming and again I think my list is still incomplete. Are there any databases for these kind of structures? I would be pleased to get relevant suggestions and help regarding my problem.
↧